Chronic rhinosinusitis with nasal polyps (CRSwNP) goes way beyond a bad sinus infection. This guide shares CRSwNP episodes, starting from the basics.
It also goes into chronic rhinosinusitis without nasal polyps (CRSsNP), since the two conditions are closely connected and often come up together.
4 episodes · Patients, families & clinicians
Chronic rhinosinusitis with nasal polyps (CRSwNP)
Learn about chronic rhinosinusitis in 3 MODULES
MODULE 1
The basics: what is chronic rhinosinusitis with nasal polyps (CRSwNP)
You can't manage something you don't understand. Before treatment, before diagnosis, it starts with knowing what's actually happening inside your body. These episodes answer the big "what" and "why" behind CRSwNP.
Start here!
Ep. 133
What Is Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)?
Dr. Rohit Katial joins to explain how nasal polyps form, why type 2 inflammation keeps driving the problem, how CRSwNP connects to asthma and allergies, and when symptoms lasting 12 weeks or more mean it's time to see a specialist.
Ep. 137
Diagnosing Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Dr. Tonya Farmer, a board-certified ENT, walks through how CRSwNP is diagnosed from a nasal endoscopy, CT scans, IgE levels, and eosinophil markers. She also explains why loss of smell is one of the most important early clues to look for.
MODULE 2
Treatment options for CRSwNP
Managing CRSwNP isn't a one-and-done situation. Because the inflammation never fully goes away on its own, treatment is something you build over time. The good news? Four biologics are now approved, a new clinical practice guideline was published in 2025, and options have improved significantly. These episodes walk you through all of them.
Ep. 109
Tezepelumab & Nasal Polyps — Inside the WAYPOINT Phase III Trial
Dr. Gupta, Kortney, and Dr. Blaiss break down this 52-week NEJM trial testing tezepelumab (Tezspire) in severe, uncontrolled CRSwNP, covering polyp size reduction, congestion, smell recovery, and fewer surgeries, and why blocking TSLP upstream of the entire T2 cascade matters.
Understand why CRSwNP keeps coming back
Type 2 inflammation connects CRSwNP to asthma, eczema, and EOE — often in the same patient.
Ep. 146
How to Treat Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Dr. Maeve O'Connor walks through the full treatment picture from saline rinses, nasal steroid sprays, surgery, and when to consider the four approved biologics: dupilumab (Dupixent), omalizumab (Xolair), mepolizumab (Nucala), and tezepelumab (Tezspire).
MODULE 3
Without nasal polyps
Chronic rhinosinusitis doesn't always come with polyps, but it can still take over your life. CRSsNP is a distinct condition that often gets written off as recurring infections or seasonal allergies, leaving many people suffering for years without a real answer. If your symptoms feel familiar but nothing mentioned in the above modules quite fits, this is where to start.
Ep. 149
What Is Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)?
Dr. Anju Peters, co-author of the 2025 Adult Sinusitis Clinical Practice Guideline, and Dr. Michael Blaiss explain what CRSsNP is, why antibiotics alone aren't the answer, how it differs from CRSwNP, and the wider impacts on sleep, mood, and quality of life that most people never connect back to their sinuses.
CRSsNP Diagnosis and Treatment coming Summer 2026o